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Get the Answers to the Most Asked Ovarian Cancer Questions in New Video Series from Dr. Beth Y. Karlan

Beth Y. Karlan, MDOctober 1, 2014

Our favorite part of Run for Her is building relationships with ovarian cancer patients, survivors and supporters. Over the past 10 years, we’ve been asked many questions by our supporters. What are the symptoms of ovarian cancer? What are some of the latest research advances in the field of ovarian cancer? How does the Women’s Cancer Program use the money raised by Run for Her?

These questions, among others, are very important – and we are so fortunate that our participants are engaged enough to ask! We sat down with Dr. Beth Karlan to address these questions and bring to light the importance of not only Run for Her, but the groundbreaking research efforts produced by her team of physicians and scientists. We will be sharing these videos with you over the coming weeks.

First up, Dr. Karlan explains why research has been seemingly slower for ovarian cancer than for other cancers.

Categories: From the Desk of Dr. Karlan No Comments, Leave a Reply

Dr. Mary-Claire King Recognized with the Lasker-Koshland Special Achievement Award in Medical Science

Kelli SargentSeptember 9, 2014

Yesterday the 2014 Albert and Mary Lasker Foundation awards were announced and Dr. Mary-Claire King was recognized with the Lasker-Koshland Special Achievement Award in Medical Science.

Dr. King is noted for her discovery of the BRCA1 gene.  When the BRCA1 gene mutates it causes increased vulnerability to breast cancer.   “Dr. King’s work over the past several decades has largely laid the foundation for many of the advances we have today in prevention and care for persons with an inherited risk of cancer due to the BRCA gene,” said Dr. Beth Karlan, director of the Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute. Dr. Karlan, who counts Dr. King among her personal and professional role models, added, “Thanks to Dr. King’s groundbreaking achievement in genetics, women today can learn if they carry a genetic mutation, and with their physician develop a prevention plan that is right for them and their family.”

The Lasker Awards are often called the “American Nobels” in medical science. Since 1942, 86 Lasker laureates have gone on to receive Nobel Prizes in medicine and medical research.

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Why we Run for Her in the Bay Area

Sarah DeSimoneAugust 5, 2014

Sarah DeSimone tells us why we Run for Her in the Bay Area and how her family is the genesis behind it.


On December 14, 2012, my family was forever changed. That was the day my mother was diagnosed with stage IV ovarian cancer. We were in complete shock; we didn’t know what to do or where to turn for support. A few months after the diagnosis, I felt a strong need to do something, anything, for the ovarian cancer cause.

That is when I found Run for Her, which has changed everything for my family. My mom, dad, husband, and son participated in the 2013 Los Angeles walk two months after my mom finished chemo.  We proudly came in last place! After feeling so alone in this journey, it was amazing to be part of something where I immediately felt so much love, support, and hope. My mom and I knew this was something we wanted to bring to the Bay Area.

I emailed Kelli Sargent about bringing Run for Her to Northern California, and, to my surprise, she graciously agreed to meet with my mom, my sister, and me. Kelli’s positive energy and belief in us was truly overwhelming. We were thrilled that she wanted to work with us!

From day one, my mom has led the effort to make the inaugural Run for Her Bay Area a successful event. From organizing committees to collaborating with different companies, my mom works tirelessly on the event every day. As she starts her second round of chemo, she is also bookmarking her calendar to put up Run for Her posters, attend committee meetings, and go out and garner support any way she can. Our conversations have turned from “How could this happen to us?” to “What can we do to help stop this from happening to any other woman and family?” Run for Her gives that to every person involved: the opportunity to make a difference. And that is a true gift.

- Sarah DeSimone

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Cedars-Sinai Experts Recommend Annual Pelvic Exams

AdministratorJuly 3, 2014

Annual pelvic exams are still an important tool in the overall assessment of a woman’s health, say physicians in the Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute.

Recently, the American College of Physicians (ACP) recommended that annual pelvic exams be eliminated for average-risk, asymptomatic women. The ACP speculated false-positive results could cause potential harm.

Cedars-Sinai women’s cancer experts disagree. “We continue to support the position of the American Board of Obstetrics and Gynecology (ABOG) and their recommendation for annual pelvic exams for women over 21 years of age,” said Beth Y. Karlan, MD, Director of the Cedars-Sinai Women’s Cancer Program.

Women should visit their healthcare providers yearly. “The decision of whether or not to conduct a pelvic exam should be made on an individual basis between the physician and the patient,” added Dr. Karlan.

BJ Rimel, MD, gynecologic oncologist in the Women’s Cancer Program, explains more about the procedure, which her team considers an “important adjunct” to regular physicals. While the pelvic exam has its limitations, says Dr. Rimel, “that doesn’t preclude the possibility or probability that some patients will distinctly benefit from this non-invasive exam.”

Categories: Ovarian Cancer Awareness No Comments, Leave a Reply

New Guidance for Care of Women With BRCA Mutation

Beth Y. Karlan, MDMarch 3, 2014

If you were watching the news or following social media last week, you may have seen this headline: Women with BRCA1 mutations should remove ovaries by age 35. Many major media outlets reported this story, and it is based on study results that appeared in the February 24 issue of the Journal of Clinical Oncology.

The Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute and our Gilda Radner Hereditary Cancer Program participated in this study and the analysis of the results, and I am an author on the report, entitled Impact of Oophorectomy on Cancer Incidence and Mortality in Women with a BRCA1 or BRCA2 Mutation. The research is based on data from an international registry of almost 6,000 BRCA carriers, some with cancer and some without. Our goal was to estimate the benefit ofrisk-reducing salpingo-oophorectomy surgery (removing the ovaries and fallopian tubes) in patients who have a BRCA1 or BRCA2 mutation. Read On

Categories: From the Desk of Dr. Karlan, Ovarian Cancer Research No Comments, Leave a Reply